Several oncogenic miRNAs can promote PTX resistance, such as miR-21, miR-23a and miR-155-5p. Can I Avoid or Limit My Exposure to X-rays and Gamma Rays? Shang Y, Zhang Z, Liu Z, Feng B, Ren G, Li K, et al. 2016;22:350613. Select theLiveChat button at the bottom of the page. RNA Biol. Involvement of miR-20a in promoting gastric cancer progression by targeting early growth response 2 (EGR2). 2017;13(6):483742. $53.99 Make It a Routine. Lan WG, Xu DH, Xu C, Ding CL, Ning FL, Zhou YL, et al. Ther Adv Med Oncol. The American Cancer Society is a qualified 501(c)(3) tax-exempt organization. 2011;3(3):8392. 2019;18(1):14552. This warning is often in the form of a label on the product or its packaging. SNORA42 enhances prostate cancer cell viability, migration and EMT and is correlated with prostate cancer poor prognosis. Li G, Yang F, Gu S, Li Z, Xue M. MicroRNA-101 induces apoptosis in cisplatin-resistant gastric cancer cells by targeting VEGF-C. Mol Med Rep. 2016;13(1):5728. 2014;21(1):34350. Zhou X, Men X, Zhao R, Han J, Fan Z, Wang Y, et al. A novel circular RNA circFN1 enhances cisplatin resistance in gastric cancer via sponging miR-182-5p. Long noncoding RNA MALAT1 regulates autophagy associated chemoresistance via miR-23b-3p sequestration in gastric cancer. Chang L, Guo F, Wang Y, Lv Y, Huo B, Wang L, et al. Article Businesses are not required to use this exact wording (as long as it still provides a clear and reasonable warning), so it can vary somewhat between labels. Shang C, Sun L, Zhang J, Zhao B, Chen X, Xu H, et al. 2018;41(4):195866. LW and MY conceived the review, acquired data, provided project funding, writing and reviewing the manuscript. A. GNC Total Lean Lean Shakes (pre-mixed) Drink 5 shakes a day, approximately one every 3 hours. Doxorubicin combined with Notch1-targeting siRNA for the treatment of gastric cancer. Wei Y, Liu Z, Fang J. H19 functions as a competing endogenous RNA to regulate human epidermal growth factor receptor expression by sequestering let7c in gastric cancer. PubMed Central Mol Cancer. Zhou Z, Lin Z, He Y, Pang X, Wang Y, Ponnusamy M, et al. 2.33 Pound (Pack of 1) 4.4 out of 5 stars 630. Add to Cart. Save money by finding high-quality products at lower cost. * We do not sell or share your personal information with anyone else, ever. The Lean Shake that started it all! In addition, ectopic miR-200c has been found to sensitize SGC7901/DDP resistance gastric cancer cells to DDP through inhibiting expression of E-cadherin, Rho family GTPase 3 (RhoE) and ZEB2 [75, 108, 109]. Purchase this product at GNC or www.gnc.com. 2019;118:109255. Mol Cancer. Li M, Zhang YY, Shang J, Xu YD. On the contrary, several tumor suppressor miRNAs can reverse 5-FU resistance of gastric cancer. Exp Biol Med (Maywood). Shao F, Huang M, Meng F, Huang Q. Circular RNA Signature Predicts Gemcitabine Resistance of Pancreatic Ductal Adenocarcinoma. Zhang X, Bo P, Liu L, Zhang X, Li J. Overexpression of long non-coding RNA GHET1 promotes the development of multidrug resistance in gastric cancer cells. Yu Y, Yu X, Liu H, Song Q, Yang Y. miR494 inhibits cancerinitiating cell phenotypes and reverses resistance to lapatinib by downregulating FGFR2 in HER2positive gastric cancer. Interestingly, several miRNAs, lncRNAs and circRNAs have been found to play an essential part in gastric cancer drug resistance, especially in chemoresistance. 2013;45(11):96372. Californias Proposition 65, also called the Safe Drinking Water and Toxic Enforcement Act, first became law in the state in 1986. A significantly elevated miR-21 expression was observed in PTX resistant SGC7901/PTX gastric cancer cells compared to the parent SGC7901 cells. For instance, significantly diminished expression of lncRNA CASC2 was observed in DDP-resistant gastric cancer tissues and cells. 2018;102:13850. California Office of Environmental Health Hazard Assessment. Nevertheless, primary drug resistance or acquisition drug resistance eventually lead to treatment failure and poor outcomes of the gastric cancer patients. 2014;59(2):33645. 5-fluorouracil: mechanisms of action and clinical strategies. Answer: This warning is legally required by the state of California for dietary supplements and many other products sold in that state which expose you to levels of one or more chemicals that may cause cancer or reproductive harm. Huang H, Tang J, Zhang L, Bu Y, Zhang X. miR-874 regulates multiple-drug resistance in gastric cancer by targeting ATG16L1. Additionally, miR-501 was also identified in SGC7901/ADR cells-secreted exosomes (ADR Exo) with a relatively high level. 2015;21(5):3139. Trastuzumab, a US Food and Drug Administration (FDA) approved anti-human HER2 MoAb, combined with conventional chemotherapy has been broadly used in advanced or metastatic gastric cancer patients with HER2 overexpression/amplification. 60 Count (Pack of 1) 4.3 out of 5 stars 1,185. Oncogenic miR-17 has been found to reduce 5-FU sensitivity of gastric cancer cells through silencing expression of DEDD [129]. Staying Healthy The hidden dangers of protein powders August 15, 2022 They may contain added sugar, calories, or even toxic chemicals. Li M, Gao M, Xie X, Zhang Y, Ning J, Liu P, et al. 2019;2019:9325407. It has been observed that significantly changed miRNA expression profiles in drug-resistant gastric cancer cells compared to those in drug-sensitive cells. By modulating Annexin A2 (ANXA2) and VEGF-C expression, tumor suppressor miR-101 has been found to reverse DDP resistance of gastric cancer cells [110, 111]. miR215p confers doxorubicin resistance in gastric cancer cells by targeting PTEN and TIMP3. 2014;15(1):4963. Yu J, Ding WB, Wang MC, Guo XG, Xu J, Xu QG, et al. MiR-23a, which is dramatically up-regulated in human gastric cancer tissues, has been shown to weaken PTX-induced apoptosis and accelerate proliferation of BGC823 and MGC803 gastric cancer cells via suppressing expression of interferon regulator factor 1 (IRF1) [144]. Ectopic miR-200c could sensitize SGC7901/DDP cell to ADR, cisplatin (DDP) and 5-FU through suppressing expression of Bcl-2 and Bax expression [75]. Exp Ther Med. 2019;120:19406. Wilke H, Muro K, Van Cutsem E, Oh SC, Bodoky G, Shimada Y, et al. Often these ingredients are not the primary ingredient in a product, but are part of a blend or proprietary formula added to enhance the product or distinguish it in the marketplace. Featured: Have cancer and want to quit smoking? MicroRNA-195 and microRNA-378 mediate tumor growth suppression by epigenetical regulation in gastric cancer. Correlation between immune-related adverse events and prognosis in patients with gastric cancer treated with nivolumab. Peng QP, Du DB, Ming Q, Hu F, Wu ZB, Qiu S. MicroRNA 494 increases chemosensitivity to doxorubicin in gastric cancer cells by targeting phosphodiesterases 4D. MicroRNA-185 regulates chemotherapeutic sensitivity in gastric cancer by targeting apoptosis repressor with caspase recruitment domain. Int J Biochem Cell Biol. Arch Virol. Du X, Liu B, Luan X, Cui Q, Li L. miR-30 decreases multidrug resistance in human gastric cancer cells by modulating cell autophagy. 170. 2019;459:12234. Biochem Biophys Res Commun. Contactless delivery and your first delivery or pickup order is free! Xing F, Wang S, Zhou J. Arch Pathol Lab Med. Article Exosomal transfer of miR-501 confers doxorubicin resistance and tumorigenesis via targeting of BLID in gastric cancer. Interestingly, Epstein-Barr (EB) virus miRNA miR-BART20-5p could also significantly increase ADR resistance of gastric cancer by inhibiting gene expression of BAD, a Bcl-2 family member [56]. Eur Rev Med Pharmacol Sci. In addition, the annular structure endows circRNAs with inherent stability, which enables them to accumulate in exosomes and exist stably in peripheral body fluids such as plasma and saliva. 2015;34:28. 5-FU is commonly applied for the treatment of gastric cancer in clinic. MiR-20a was also proved to enhance gastric cancer resistance to ADR via inhibiting expression of early growth response 2 (EGR2), a member of a multi-gene family which encoding C2H2-type zinc-finger proteins [60]. Zhu W, Shan X, Wang T, Shu Y, Liu P. miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines. A Competing Endogenous RNA Network Reveals Novel Potential lncRNA, miRNA, and mRNA Biomarkers in the Prognosis of Human Colon Adenocarcinoma. For more information and frequently asked questions about Proposition 65, go to:https://www.p65warnings.ca.gov. Onco-lncRNAs zinc finger antisense 1 (ZFAS1) and BCAR4 could promote DDP resistance of gastric cancer via activating the Wnt signaling pathway [173, 174]. Wang M, Zhang R, Zhang S, Xu R, Yang Q. MicroRNA-574-3p regulates epithelial mesenchymal transition and cisplatin resistance via targeting ZEB1 in human gastric carcinoma cells. Ock CY, Keam B, Kim S, Lee JS, Kim M, Kim TM, et al. All these elucidate the potential of circRNAs as markers for diagnosis and therapy of cancers [193,194,195]. What the labels say and don't say. Biomed Pharmacother. ConsumerLab.com generally applies the Prop 65 limits when testing for contaminants in supplements. 2019;10(4):103951. This means that not every chemical on the list has been proven to the worldwide scientific community to actually cause cancer in people. Han X, Zhang JJ, Han ZQ, Zhang HB, Wang ZA. Zhu P, Zhang J, Zhu J, Shi J, Zhu Q, Gao Y. MiR-429 Induces Gastric Carcinoma Cell Apoptosis Through Bcl-2. Onco Targets Ther. Currently, platinum-based chemotherapy is a standard treatment for gastric cancer patients. 2016;35(48):6189202. CAS To the best of our knowledge, there are no reports on miRNAs, lncRNAs and circRNAs involved in drug resistance to immune-checkpoint blockade agents in gastric cancer. Your privacy choices/Manage cookies we use in the preference centre. Shen B, Yu S, Zhang Y, Yuan Y, Li X, Zhong J, et al. MicroRNA-623 Targets Cyclin D1 to Inhibit Cell Proliferation and Enhance the Chemosensitivity of Cells to 5-Fluorouracil in Gastric Cancer. Pang X, Zhou Z, Yu Z, Han L, Lin Z, Ao X, et al. Int J Oncol. Foxo3a-dependent miR-633 regulates chemotherapeutic sensitivity in gastric cancer by targeting Fas-associated death domain. www.consumerlab.com/answers/why-does-my-supplement-have-a-warning-label-from-the-state-of-california/cancer-warning-on-labels/. Yi C, Wan X, Zhang Y, Fu F, Zhao C, Qin R, et al. This means the OEHHA cannot offer information to help consumers figure out what the potential risk is with a specific product or how to avoid it. Multiple miRNAs are dysregulated in gastric cancer and play a crucial role in tumorigenesis, cancer metastasis, as well as development of resistance to drugs and radiation [44,45,46,47,48]. Upregulation of microRNA-524-5p enhances the cisplatin sensitivity of gastric cancer cells by modulating proliferation and metastasis via targeting SOX9. Xu W, He L, Li Y, Tan Y, Zhang F, Xu H. Silencing of lncRNA ZFAS1 inhibits malignancies by blocking Wnt/beta-catenin signaling in gastric cancer cells. People living in areas with serious air pollution and those who smoke and drink for a long time belong to high-risk groups. Teng R, Hu Y, Zhou J, Seifer B, Chen Y, Shen J, et al. Due to lack of obvious and specific symptoms at early disease stage, most gastric cancer patients were diagnosed at advanced disease stages with poor prognosis. In gastric cancer patients, ADR is commonly used in combination with platinum drugs, 5-FU, VCR, PTX and mitomycin. 2019;52(4):e12648. 2018;42(2):9981007. Kang X, Li M, Zhu H, Lu X, Miao J, Du S, et al. Recently, miR-155-5p was identified as an enriched miRNA in exosomes deriving from PTX-resistant MGC-803R gastric cancer cells. MicroRNA-200c regulates the sensitivity of chemotherapy of gastric cancer SGC7901/DDP cells by directly targeting RhoE. MiR-218 inhibits multidrug resistance (MDR) of gastric cancer cells by targeting Hedgehog/smoothened. 2017;14(5):6097102. Zhao Q, Li Y, Tan BB, Fan LQ, Yang PG, Tian Y. HIF-1alpha Induces Multidrug Resistance in Gastric Cancer Cells by Inducing MiR-27a. Longley DB, Harkin DP, Johnston PG. 2019;42(2):13141. Similarly, cirRNA hsa_circ_0081143, which is up-regulated in gastric cancer tissues, could also contribute to DDP resistance by regulating the miR-646/CDK6 pathway. 2023 ConsumerLab.com, LLC. Interestingly, lncRNA XLOC_006753, which is highly expressed in gastric cancer patients and MDR SGC-7901/DDP gastric cancer cells, could promote resistance to DDP through regulating the PI3K/AKT/mTOR pathway [172]. The law also has similar strict cutoff levels for birth defects and reproductive harm. miR-135a promotes gastric cancer progression and resistance to oxaliplatin. PubMed People who buy new electrical products are often concerned when they see these warning labels, but cords have contained lead for many years. It has been found that several oncogenic or tumor suppressive miRNAs are involved in VCR resistance (Table 4). Circ-SERPINE2 promotes the development of gastric carcinoma by sponging miR-375 and modulating YWHAZ. Cancer Sci. Cords with lead inside their covering, and cords that are in places that make them inaccessible to consumers during ordinary use do not have to be labeled. Tumor suppressor miR-34a has also been shown to sensitize gastric cancer cells to PTX via inhibiting expression of oncoprotein E2F5 [148]. Accessed at https://www.p65warnings.ca.gov/new-proposition-65-warnings on May 6, 2019. This warning is legally required by the state of California for dietary supplements and many other products sold in that state which expose you to levels of one or more chemicals that may cause cancer or reproductive harm. Xie X, Huang N, Zhang Y, Wei X, Gao M, Li M, et al. 2023 BioMed Central Ltd unless otherwise stated. MiR-421, a highly expressed miRNA in advanced gastric cancer patients, could also promote gastric cancer metastasis and DDP resistance through inhibiting E-cadherin and caspase-3 expression, in vivo and in vitro [91].