Perennials need to be planted just once and will return year after year. Thanks for your business. They always get good marks for their service. Warning: mysqli_query() expects parameter 1 to be mysqli, boolean given in /var/www/vhosts/www.waltersgardens.com/httpdocs/api/cms_PageImage.php on line 511 They bill themselves as being plants for western gardens, but they have such a great collection of drought-tolerant xeriscape plants and so much information that I would recommend them for any area, except maybe the extreme south. 0.0013 656264 3. Read more Preplanned Perennial Gardens & Collections Planning a garden takes time and a degree of know-how. Welcome to the largest wholesale perennials catalog online! PDF ABB Beyond expectations Over the years, multiple landmark phase 3 trials have introduced efficacious therapeutic options for the frontline therapy of patients with CLL. How does a physician advise a patient with CLL as to which is the best regimen for that specific individual? VO has a fixed duration (12 months) with a goal of inducing MRD remissions and allowing patients a period of time between therapeutic interventions. Warning: mysqli_query() expects parameter 1 to be mysqli, boolean given in /var/www/vhosts/www.waltersgardens.com/httpdocs/api/cms_Page.php on line 69 Therefore, a patient who is not a candidate for lifelong therapy secondary to lack of compliance or patient preference may not be the best candidate for ibrutinib therapy. The stop for great houseplants, tropicals, and tender perennials. These landscape roots and our growing experience have given us valuable insight into the needs of todays gardeners. The action you just performed triggered the security solution. Call Stack: The published clinical trials evaluating the frontline VO regimen have short median follow-up times with the longest at 28 months.19 The published clinical trials evaluating the frontline ibrutinib regimen have longer follow-up times (up to 60 months).20 Therefore, long-term efficacy, including durability of remissions, and toxicity data in patients receiving the fixed-duration VO regimen are not yet available. SHOP NOW FEATURED BEST SELLERS Hemerocallis 'Happy Returns' (Daylily) Shop Now Anemone x hybrida 'Pamina' (Windflower) Shop Now Sedum x 'Autumn Joy' (Stonecrop) Shop Now Carex oshimensis EverColor Everest (Sedge) Shop Now Agastache x Kudos Coral (Dwarf Hummingbird Mint) Shop Now Verbascum x 'Dark Eyes' (Mullein) Shop Now They have always specialized in carrying seeds of great tasting produce with advice on how to prepare it. During the first month of obinutuzumab therapy and the 5-week ramp-up of venetoclax, facilities and staffing are required for rapid turnaround times to monitor TLS laboratory parameters and for careful timely review of these results. Table 2 compares key features of the currently approved regimens that should be considered when recommending frontline therapy for a patient with CLL. Call Scott and ask about any of your plant needs. Perennials are not always maintenance-free. We are open and looking forward to seeing you soon! You can nowsource fromtwelve catalogs in one reading. 0.0000 637224 1. Seeds and gardening supplies from and for the northeast U.S., with an emphasis on sustainability and buying local. _read() /var/www/vhosts/www.waltersgardens.com/httpdocs/global.php:100 How we work. Choosing a selection results in a full page refresh. Obinutuzumab is a type II humanized antibody that promotes direct cytotoxicity and features an afucosylated Fc region that promotes antibody-dependent natural killer (NK)cellmediated cytotoxicity.15 In primary CLL cells, obinutuzumab treatment demonstrated superior cytotoxicity and antibody-dependent NK-cellmediated cytotoxicity when compared with rituximab treatment.15 These preclinical data translated to clinical data in the CLL11 study where CLL patients treated with frontline obinutuzmab and chlorambucil had prolonged PFS, OS, and higher rates of CR compared with patients treated with frontline rituximab and chlorambucil.3,16 Based upon this study, obinutuzumab and chlorambucil earned FDA approval for marketing for frontline therapy of CLL. Annie's began by specializing in seed-grown annuals and expanded to include perennials. Erin Huffstetler is a frugal living expert who has been writing for over 10 years about easy ways to save money at home. We offer thousands of varieties in fourteen sizes from the country\'s top growers in one comprehensive catalog. sales@waltersgardens.com • 1-800-WALTERS • Privacy Notice This includes hard-to-find specimen plants that Scott grafts himself. With the goals of limiting toxicity and improving efficacy, therapies designed to specifically target CLL cells were developed. High Mowing Organic Seeds is a Vermont based, family owned business that sells only 100% Certified Organic seed. While all plants listed below are perennials, they may not grow perennially in all locations. 0.0000 637224 1. Fetchcms_PageArticleGetSet() /var/www/vhosts/www.waltersgardens.com/httpdocs/api/cms_PageArticle.php:354 Due to the significant efficacy and tolerability of venetoclax in patients with R/R CLL, the next rational place to study venetoclax was the frontline setting. Our state of the art search feature brings the marketplace to you in seconds. 0.0031 666464 2. cms_PageImageLoadList() /var/www/vhosts/www.waltersgardens.com/httpdocs/perennials.php:32 0.0000 637224 1. In this study, obinutuzumab was administered IV at doses of 100 mg on cycle 1 day 1 (C1D1), 900 mg on C1D2, and 1000 mg on C1D8, C1D15, and C2-6D1. has received research funding from Gilead, Karyopharm, and Acerta. CRR, complete response rate; DOR, duration of response; NA, not available; NR, not reached. Ordering • Now she travels the world looking for interesting and unusual vegetable and flower seeds, testing them herself and then offering the best to us. Online only, no catalog. Call Stack: We've eliminated the need tonavigate from list to list. {main}() /var/www/vhosts/www.waltersgardens.com/httpdocs/perennials.php:0 Notably, all 3 of the patients had laboratory evidence of tumor lysis.11 A subsequent phase 1 study for 116 patients with heavily pretreated CLL demonstrated an impressive 79% ORR in this high-risk group.12 Notably, 20% of these patients achieved CR, including 5% of patients without detectable MRD, a feature that distinguishes venetoclax from responses seen with single-agent ibrutinib.12 In this early study, clinical development of venetoclax in CLL was nearly thwarted by significant clinical events of tumor lysis syndrome (TLS). Adams Fairacre Farms Gardening Perennials. At 3 months following treatment completion, 76% and 57% of patients were MRD in the peripheral blood and bone marrow, respectively. {main}() /var/www/vhosts/www.waltersgardens.com/httpdocs/perennials.php:0 Both preclinical and clinical data suggested that combining venetoclax with obinutuzumab (VO; a third-generation anti-CD20 monoclonal antibody) could optimize clinical outcomes such as response, attainability of MRD status, and survival for patients with previously untreated CLL. Cloudflare Ray ID: 7ebf0eff9df12806 {main}() /var/www/vhosts/www.waltersgardens.com/httpdocs/perennials.php:0 It is notable that although the median ages of patients treated on the RESONATE2 and CLL14 studies were similar (73 vs 72 years), only 69% of patients treated on the RESONATE2 study had CIRS >6 or reduced creatinine clearance compared with 100% of the patients treated on the CLL14 study.5,19,21 It is also notable that the recently published E1912 study specifically evaluated an ibrutinib-based regimen in younger and healthy patients with CLL.7. One of the best catalogs for flower seeds. Subsequently, the phase 3 MURANO study evaluated venetoclax therapy in patients with R/R CLL.14 The study compared the combination of venetoclax (fixed duration, 2 years) and rituximab (anti-CD20 monoclonal antibody; fixed duration with 6 monthly doses) to bendamustine and rituximab in patients with R/R CLL.14 The study met its primary end point by demonstrating a 2-year PFS rate of 85% in patients who received venetoclax and rituximab as compared with 36% in patients who received bendamustine and rituximab.14 This PFS advantage was maintained across all high-risk groups including patients with del(17p) karyotype and unmutated immunoglobulin heavy chain variable region (IGHV) status.14 The ORR demonstrated in patients who received venetoclax and rituximab was an impressive 92% with 84% of these patients achieving MRD status in the peripheral blood during the trial.14 Based on the MURANO study, venetoclax in combination with rituximab was granted full FDA approval for marketing for all patients with R/R CLL on 8 June 2018. 0.0002 639064 2. require_once('/var/www/vhosts/www.waltersgardens.com/httpdocs/global.php') /var/www/vhosts/www.waltersgardens.com/httpdocs/perennials.php:2 Breck's Iris Lovers All-Natural Iris Food 1 for $9.99. The Perennial Farm - Official MapQuest Growing Heirloom Perennial Flowering Plants - Many Rare, All Classic. Search for: My Account; Home; Shop Daylilies. Venetoclax in combination with obinutuzumab is an efficacious and tolerable combination that provides a fixed-duration, chemotherapy-free option for patients with previously untreated chronic lymphocytic leukemia (CLL). FetchYearGetSet() /var/www/vhosts/www.waltersgardens.com/httpdocs/api/Year.php:324 Call Stack: You can email the site owner to let them know you were blocked. Call Stack: 0.0032 669288 4. mysqli_query() /var/www/vhosts/www.waltersgardens.com/httpdocs/api/cms_PageArticle.php:331 250 Union Church Road Dillsburg, PA 17019. Without prospective head-to-head comparison of these agents in this setting, it remains unclear which regimen is most efficacious for all CLL subgroups, especially the patients with del(17p). Do you have a section on local/native plants. 0.0031 666464 2. cms_PageImageLoadList() /var/www/vhosts/www.waltersgardens.com/httpdocs/perennials.php:32 Administration of VO requires 8 IV infusions of obinutuzumab. These perennials can be added to the landscape after they . Order Toll-Free - 800-532-9545. 0.0027 666200 4. mysqli_query() /var/www/vhosts/www.waltersgardens.com/httpdocs/api/w_Cfg.php:47 Shade plants need little or no sun to thrive. For more great plant catalog listings, keep reading. Provide your address and we'll mail you a copy of our most recent Oakes Daylilies catalog. You can unsubscribe at any time by clicking the unsubscribe link in any email you receive from us. Your IP: Until then, predicting outcomes of second-line therapy after frontline venetoclax is an extrapolation. Warning: mysqli_query() expects parameter 1 to be mysqli, boolean given in /var/www/vhosts/www.waltersgardens.com/httpdocs/global.php on line 118 Choose from the new and unusual to old favorites. There are pros and cons to growing perennials and it helps to know them both. A large selection of reasonably priced perennials. Warning: mysqli_fetch_assoc() expects parameter 1 to be mysqli_result, null given in /var/www/vhosts/www.waltersgardens.com/httpdocs/api/cms_PageImage.php on line 525 YearLoadList() /var/www/vhosts/www.waltersgardens.com/httpdocs/global.php:147 Quality grown products for independent garden centers and nurseries. Call Stack: Client Login | Quality Greenhouses & Perennial Farm Inc. Like Us on Facebook. They can all be found online and most will send you a free print catalog, which you can order from their websites. Shop A - Z - Far Reaches Farm 0.0006 650064 3. session_start() /var/www/vhosts/www.waltersgardens.com/httpdocs/global.php:100 0.0000 637224 1. Most perennials don't produce food for the first three to five years. Here's a list of catalogs offering garden "extras.". The companies listed here are popular for both the products and plants they offer and the information their catalogs contain. At this time, there are several ongoing large phase 3 studies for patients with previously untreated CLL to evaluate for superiority of venetoclax-based combinations when compared with standard-of-care agents (NCT02950051, NCT03462719, NCT03737981, NCT03701282). By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Everything was packaged well that nodamage at all could have occurred during shipping! 0.0002 639064 2. require_once('/var/www/vhosts/www.waltersgardens.com/httpdocs/global.php') /var/www/vhosts/www.waltersgardens.com/httpdocs/perennials.php:2 The catalog is like reading a book. As assessed in 26 available patients after 18 cycles of ibrutinib and venetoclax combination therapy. Over the years, multiple landmark phase 3 trials have introduced efficacious therapeutic options for the frontline therapy of patients with CLL.1-3 Regimens containing standard cytotoxic chemotherapy agents (fludarabine, cyclophosphamide, bendamustine, and chlorambucil) in combination with anti-CD20 monoclonal antibodies (rituximab and obinutuzumab) were considered the standard of care for many years. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. Quality Greenhouses & Perennial Farm, Inc.Quality Greenhouses & Perennial Farm Inc. Who We Are We are a wholesale grower of annuals and perennials, focused on providing independent garden centers and nurseries with a 'quality grown' product and selection that includes new and unique varieties. A lot more goes into a great garden than just plants. 0.0011 652448 3. mysqli_query() /var/www/vhosts/www.waltersgardens.com/httpdocs/global.php:126 The catalog costs $4.95, but it is redeemable with your first order. Treating physicians have the benefit of tailoring treatment specifically to the individual patient based on treatment goals, preference for length of therapy, and side-effect profile. Free planting guide, instructions and easy-to-follow diagrams with each order. Renee Sheperd is the founder of Sheperd's Garden Seeds, which she sold to White Flower Farm. Correspondence: Deborah M. Stephens, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Research South 5509, Salt Lake City, UT 84112; e-mail: deborah.stephens@hci.utah.edu. Warning: mysqli_real_escape_string() expects parameter 1 to be mysqli, boolean given in /var/www/vhosts/www.waltersgardens.com/httpdocs/sessions.php on line 22 There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. Seeds and supplies for the home gardener and commercial grower, featuring a section devoted to certified organic seed and a tempting gourmet Italian vegetable seed collection. Lots of seed varieties you won't find elsewhere. • P.O. 0.0031 666464 3. cms_PageImageGetQuery() /var/www/vhosts/www.waltersgardens.com/httpdocs/api/cms_PageImage.php:534 It bears mentioning that some perennials can spread to the point of becoming invasive. {main}() /var/www/vhosts/www.waltersgardens.com/httpdocs/perennials.php:0 On the venetoclax combination arm, the daily venetoclax regimen was initiated on C1D22 with the standard 4-week dose ramp-up (1 week each of 20, 50, 100, and 200 mg) to the targeted continuous dose of 400 mg daily. We are pleased to be one of the finest flower farms in Syracuse NY with one of the largest selections of perennials, ornamental grasses, hostas, and flowers. Many ongoing studies will further define the ideal combination and long-term efficacy of these novel therapies in a prospective manner. She's also an author of three gardening books, a plant photographer, public speaker, and a former Cornell Cooperative Extension Horticulture Educator. Well-priced, quality tools and gadgets, not just for the garden. Availability The Perennial Farm Once your plants are established, they'll be less susceptible to drought or other unfavorable growing conditions. ONCE Season-Long Plant Food 1 for $24.99. Venetoclax is an oral BCL2 homology domain 3 (BH3) mimetic that disrupts antiapoptotic signaling via BCL2, thereby inducing CLL cell death.11, Venetoclax formally entered the clinical trials for CLL patients in 2011 when a first-in-human study initially enrolled and treated 3 patients with relapsed/refractory (R/R) CLL. 162.214.225.223 0.0002 639064 2. require_once('/var/www/vhosts/www.waltersgardens.com/httpdocs/global.php') /var/www/vhosts/www.waltersgardens.com/httpdocs/perennials.php:2 Received my plantabout a month ago. If its an old favorite youre seeking, we have those, too. _read() /var/www/vhosts/www.waltersgardens.com/httpdocs/global.php:100 The approval of VO has added another highly efficacious therapeutic option for the frontline treatment of patients with CLL. Warning: mysqli_fetch_assoc() expects parameter 1 to be mysqli_result, null given in /var/www/vhosts/www.waltersgardens.com/httpdocs/global.php on line 118 Perennials • Call Stack: Call Stack: This differentiates it from annuals, which must be planted each year, and biennials, which only live for two years. The current trend has directed patients away from standard chemoimmunotherapy agents, such as fludarabine, and toward targeted therapies, such as ibrutinib. Brent and Becky used to run The Daffodil Mart, which they sold to White Flower Farm. 0.0007 650608 4. 0.0000 637224 1. Will bepurchasing more plants from Perennial Farm Marketplace. Warning: mysqli_fetch_assoc() expects parameter 1 to be mysqli_result, null given in /var/www/vhosts/www.waltersgardens.com/httpdocs/api/Year.php on line 315 This Oregon based, online company is the home of LazyMan products to improve your soil. In particular, I want to highlight a few notable differences between the VO and ibrutinib regimens including length and administration of therapy, side-effect profile, duration of follow-up, and populations studied, and discuss recommendation of therapy by cytogenetic group and sequencing of therapy. White Flower Farm is a family-owned mail-order nursery located in northwestern Connecticut. Cloudflare Ray ID: 7ebf0da1380427d8 This article will briefly review the data supporting currently approved frontline therapy for CLL, detail data supporting the use of venetoclax in the frontline setting, compare key features of currently available frontline therapies, and explore future applications for venetoclax. Achieving the desired state of no detectable minimal residual disease (MRD) denoted significant depth of remission and has been associated with prolonged progression-free survival (PFS) and overall survival (OS).4 Unfortunately, these cytotoxic therapies do not specifically target CLL cells and induce significant toxicity. Plant Catalog | Morning Star Perennial Flowers 0.0008 651696 3. mysqli_fetch_assoc() /var/www/vhosts/www.waltersgardens.com/httpdocs/global.php:113 0.0002 639064 2. require_once('/var/www/vhosts/www.waltersgardens.com/httpdocs/global.php') /var/www/vhosts/www.waltersgardens.com/httpdocs/perennials.php:2 What types of perennials work best in your climate? Provide your address and we'll mail you a copy of our most recent Oakes Daylilies catalog. 0.0032 666840 3. Venetoclax was discontinued at the completion of cycle 12. All Rights Reserved. Our plant material arrives quickly and beautifully - landscape-ready for the shelves at your independent garden center or for immediate installation at your job site. If no acceptable alternative therapy is available, they should be monitored very closely for TLS in the inpatient setting during dose ramp-ups. The VO regimen provides a fixed-duration, chemotherapy-free option for patients with CLL and has been met with great enthusiasm in the CLL community. The ultimate guide to choosing and caring for perennials! 0.0002 639064 2. require_once('/var/www/vhosts/www.waltersgardens.com/httpdocs/global.php') /var/www/vhosts/www.waltersgardens.com/httpdocs/perennials.php:2 {main}() /var/www/vhosts/www.waltersgardens.com/httpdocs/perennials.php:0 Tips for Growing Perennials In Your Garden . Discover all of the different types of popular and unique plants we carry. Call Stack: At The Perennial Farm, we're growing for you! Many perennial edibles also require a fair amount of pest control. Spring Hill Nurseries: Find your Inspiration- Online Nursery Call Stack: We're ready to grow with you! {main}() /var/www/vhosts/www.waltersgardens.com/httpdocs/perennials.php:0 Browse our complete listing of perennial varieties, which most seasons runs to the hundreds, in a single convenient category. I've had it in the groundfor about a month now, and it's growing beautifully. Johnny's caters to short-season gardeners, but there's no reason others can't benefit from their collection of sure-fire performers and new introductions. 0.0007 650704 5. mysqli_real_escape_string() /var/www/vhosts/www.waltersgardens.com/httpdocs/sessions.php:22 {main}() /var/www/vhosts/www.waltersgardens.com/httpdocs/perennials.php:0 However, only 5% of these patients experienced grade 3/4 febrile neutropenia. 0.0031 666776 4. mysqli_fetch_assoc() /var/www/vhosts/www.waltersgardens.com/httpdocs/api/cms_PageImage.php:525 Call Stack: A note of caution specifically for patients with del(17p) is that very few data are available to guide recommendation of the VO regimen in the frontline setting. PerennialMarket.com was designed to make your job easier. Fetchcms_PageReadSet() /var/www/vhosts/www.waltersgardens.com/httpdocs/api/cms_Page.php:90 Catalog Request | White Flower Farm Included patients had either a Cumulative Illness Rating Scale (CIRS) score of >6 or a creatinine clearance of <70 mL/min. Our connections with industry leaders and influencers bring unique value to our wholesale customers. {main}() /var/www/vhosts/www.waltersgardens.com/httpdocs/perennials.php:0 Landscape Architects & Landscape Designers, Outdoor Lighting & Audio/Visual Specialists. They also offer a wonderful selection of grass seeds for specific needs, including native grasses, as well as flower seed, repellents and all kinds of garden supplies. {main}() /var/www/vhosts/www.waltersgardens.com/httpdocs/perennials.php:0 Healthy, well packagedand after 2 weeks already buds appearing! All Perennials by Category | White Flower Farm Our state of the art search feature brings the marketplace to you in seconds. Ibrutinib gained full FDA marketing approval for CLL therapy after the RESONATE2 study demonstrated an improved overall response rate (ORR; 86% vs 35%), 2-year PFS (89% vs 34%), and 2-year OS (98% vs 85%) when compared with chlorambucil in patients with previously untreated CLL.5 The efficacy of ibrutinib led to 2 large phase 3 studies comparing ibrutinib ( rituximab) to chemoimmunotherapy regimens in the frontline treatment of older (65 years; bendamustine and rituximab [BR]; A041202 trial) or younger (<65 years; fludarabine, cyclophosphamide, and rituximab [FCR]; E1912 trial) patients with CLL.6,7 Although both studies showed that ibrutinib-treated patients had longer PFS than those treated with chemoimmunotherapy, a notable lack in the ability of ibrutinib to induce complete response (CR) and MRD remission was observed.6,7 The chemoimmunotherapy regimens resulted in an 30% CR rate with 59% and 8% of patients who received FCR and BR, respectively, achieving MRD remissions.6,7 For patients treated with ibrutinib-containing regimens on these trials, the CR rates were <20%, and <10% of patients achieved MRD negativity in the peripheral blood.6,7 Although extended follow-up of the original RESONATE2 study suggests that remissions deepen over time with continued ibrutinib therapy, it is clear that continuous and indefinite therapy with ibrutinib is required to maintain clinical benefit.8 During the same time frame, alternate targeted therapies for CLL patients were under clinical development, including venetoclax. Now that you've seen your options, you might want to order more plant catalogs. These are bulbs from isolated, hand-pollinated seed. The goals of these regimens were to induce the deepest and longest remission possible and allow for CLL-related symptom relief for the longest possible period of time. Based on this study, the FDA approved VO for marketing for frontline therapy of all CLL patients on 15 May 2019. ABB Pulp Paper & Logistics October 2010 Favini - New QCS for PM1 Control Room Network Server & Operator Sta on Engineering Sta on Frame and Sensors TCP/IP Control Network Or just stop by! Thankfully, there are companies understand this. {main}() /var/www/vhosts/www.waltersgardens.com/httpdocs/perennials.php:0 The action you just performed triggered the security solution. Perennial Farm Marketplace 162.240.75.21 This includes hard-to-find specimen plants that Scott grafts himself. Call Stack: Although VO is the only venetoclax combination FDA-approved for marketing for the treatment of frontline CLL, many alternative combination regimens are currently under investigation. As efficacy and tolerability of the VO regimen have been established in the frontline setting for patients with CLL, the next crucial question is: could early intervention with the VO regimen in asymptomatic CLL patients improve survival compared with the standard approach of watchful waiting until development of symptomatic CLL? Call Stack: Given the proper growing conditions, these plants will enliven your low-light gardens areas. Warning: mysqli_fetch_assoc() expects parameter 1 to be mysqli_result, null given in /var/www/vhosts/www.waltersgardens.com/httpdocs/global.php on line 113 0.0000 637224 1. No clinical TLS was seen on this study.18 Eighty-two percent (24 of 29) of the patients achieved MRD status in the peripheral blood after completion of obinutuzumab therapy.18 These early studies demonstrated safety and significant efficacy for the VO combination in patients with previously untreated CLL. You also won't get the same instant gratification that you may be used to with annual foods. Before you sit back and start envisioning next year's garden, make sure you're on the mailing list for your favorite catalogs. You can email the site owner to let them know you were blocked. {main}() /var/www/vhosts/www.waltersgardens.com/httpdocs/perennials.php:0 Ibrutinib therapy is indefinite (continues as long as efficacy is maintained and no intolerable toxicity is developed). Perennials 3 Stars and above 2 Stars and above Price $0 - $400 Growing Conditions Hardiness Zone Sun / Shade Very Short-under 12" Medium-30-48" Tall-49-72" Very Tall-73" and up short-12-29" MORE WAYS TO SHOP Shop By Genus Alcea Amsonia Angelica Asarum Astilboides Centranthus Chrysanthemum (Dendranthema) Convallaria Crocosmia Cymbalaria Dianthus Home & Garden Nurseries & Gardening Cox's Plant Farm Add photo Location & Hours Suggest an edit 6360 S County Rd 0 Get directions Amenities and More Accepts Credit Cards No Bike Parking About the Business At Cox's Plant Farm, we're very unique in the way we grow our plants.