Located in southern Fresno County, District's exterior boundaries enclose approximately 163,000 acres of land, of which about 145,000 acres are irrigated agricultural land. Consolidated Irrigation District No. 2022 CCR Water Quality Report, 1521 N. Argonne Rd. When alleles enriched in such populations are causal or linked to causal variation, increased statistical power is present, enabling their detection in an association analysis (Lim et al., 2014; Prohaska et al., 2019). Join an in-person public hearing at the Consolidated Irrigation District Offices Wednesday, March 9 at 1pm Email info@cidwater.com Call (559) 896-1660 and ask . An official website of the United States government. Please note the holidays that the office is closed: New Year's Day Memorial Day Independence Day Labor Day Veteran's Day Thanksgiving Day and the Friday after A minimum one (1) acre irrigation assessment will be made against all non-vacant lands except for those lands annexed for domestic service only. SELAH-MOXEE IRRIGATION DISTRICT PO Box 166, 113 E. Moxee Avenue Moxee, WA 98936 Phone: (509) 469-0449 Fax: (509) 469-0489 Email: smidistrict@qwestoffice.net Genotypes with a HardyWeinberg Equilibrium (HWE) P-value below 1e-6, minor allele count <3, and genotyping success rate <98% were removed. Co. 24. 2, to provide water storage capacity and to provide an Operations/Maintenance building. 19 Lee H, Oh JY, Sung YA, Chung H, Kim HL, Kim GS, Cho YS, Kim JT. Department of Clinical Genetics, Faculty of Medicine and Health Technology, Tampere University Hospital and Tampere University, Tampere, Finland. Falck J, Mailand N, Syljusen RG, Bartek J, Lukas J. Goldstein JI, Crenshaw A, Carey J, Grant GB, Maguire J, Fromer M, ODushlaine C, Moran JL, Chambert K, Stevens C et al. This study also presents an interesting novel association in an intronic region of MYO10. Watanabe K, Taskesen E, van Bochoven A, Posthuma D. Functional mapping and annotation of genetic associations with FUMA. Variant positions (BP) are according to GRCh37/hg19. Every ten years, boundaries of all local governments that elect by district, including special districts like the Consolidated Irrigation District, are updated to reflect how populations have changed based on the most recent U.S. Census. This can happen if the system loses pressure. Consolidated Irrigation District 2255 Chandler St. Selma, CA 93662 . 120 N Greenacres Road Spokane Valley WA 99016 (509) 924-3656 Office hours: 8:00 am to 5:00 pm. endobj
An ex-employee of Consolidated Irrigation District in Selma was sentenced to 16 months in prison for stealing nearly a quarter of a million dollars from the agency. On March 9, 2022, the Consolidated Irrigation District Board of Directors voted to select its final district map. Read more. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. 9 0 obj
Secondly, we prioritized variants overlapping with regulatory marks, focusing on genes with modified expression or genes that showed chromatin interaction links with the variants. Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland. Ward LD, Parker MM, Deaton AM, Tu H, Flynn-Carroll A, Hinkle G, Nioi P. Rare coding variants in five DNA damage repair genes associate with timing of natural menopause. The meetings will be held on: Please complete our Prop 218 Support Form to add your name to our list of Supporters: Consolidation Irrigation District Copyright 2023 - All Rights Reserved. Two out of the three novel genome-wide significant variants associating with PCOS, rs145598156 (P = 3.610 8, odds ratio (OR) = 3.01 [2.02-4.50] minor allele frequency (MAF) = 0.005) and rs182075939 (P = 1.910 16, OR = 1.69 [1.49-1.91], MAF = 0.04), were found to be enriched in the Finnish and Estonian populations and are tightly linked to a . 2A). 2 0 obj
2017 CCR Water Quality Report Ruth KS, Day FR, Hussain J, Martnez-Marchal A, Aiken CE, Azad A, Thompson DJ, Knoblochova L, Abe H, Tarry-Adkins J et al. Computational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland. The FinnGen study combines genotype data from the Finnish biobanks with the digital health record data from the Care Register for Health Care (CRCH, from 1968 onwards) and the cancer (1953), cause of death (1969), and medication reimbursement (1995) registries (https://www.finngen.fi/en). Bidirectional Mendelian randomization to explore the causal relationships between body mass index and polycystic ovary syndrome. 19 2020 ASSESSMENTS, RATES AND ALLOWANCES Inside District A minimum one (1) acre irrigation assessment will be made against all non-vacant lands except for those lands annexed for domestic service only. Testing is due annually, and failure to provide acceptable test results by the due date may result in fines. The population-specific imputation reference of 2297 whole-genome sequencing samples was used (Mitt et al., 2017). For each genome-wide significant (P < 5108) GWAS variant, we extracted the 1-Mb radius of its top hit from the QTL datasets. The age- and BMI-adjusted GWAS meta-analysis summary statistics are available for download from the GWAS Catalog with accession numbers GCST90044902 and GCST90044903. Samples were genotyped and PLINK format files were created using Illumina GenomeStudio v2.0.4. Day FR, Hinds DA, Tung JY, Stolk L, Styrkarsdottir U, Saxena R, Bjonnes A, Broer L, Dunger DB, Halldorsson BV et al. S2). ), 297338 (J.K.), 307247 (J.K.), 344695 (H.L. 13 were here. PCOS is a common, complex disorder with unknown aetiology. 9Y#SVQ
u[?S0i(qn/(sH-Rh JypSh"E(=&JPFq@0pV5zu+ }y8~.Fx[hS.]_uoj!xvfn? A meta-analysis was performed for the FinnGen and EstBB GWAS incorporating a total of 3609 women with PCOS and 229788 controls. We prioritized variants that were more likely to have a functional consequence, such as variants in high linkage disequilibrium (LD) (r2 > 0.6) with missense mutations or pathogenic variants. 1A). 22 were here. S3) (Day et al., 2018). Meijers-Heijboer H, van den Ouweland A, Klijn J, Wasielewski M, de Snoo A, Oldenburg R, Hollestelle A, Houben M, Crepin E, van Veghel-Plandsoen M et al. Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Consolidated Irrigation District Year: County: Fresno County Special District Type: Irrigation Activity performed by this Special District: Water Enterprise Download all employee information for this special district: CSV Employees 37 Total Wages $1,568,273 Total Retirement & Health Contribution $392,499 Blank form to provide to your certified tester , Email a photo of the completed Backflow Report to. endobj
Funding was acquired by T.T.P., T.L., J.K. and H.L. Veikkolainen V, Ali N, Doroszko M, Kiviniemi A, Miinalainen I, Ohlsson C, Poutanen M, Rahman N, Elenius K, Vainio SJ et al. The criteria result in a prevalence as high as 18% for PCOS among fertile-aged women and produce several phenotypes (March et al., 2010; Skiba et al., 2018). The authors declare no conflicts of interest. CONSOLIDATED IRRIGATION DISTRICT #19 120 N Greenacres Road Spokane Valley, WA 99016 Phone: (509) 924-3655 Fax: (509) 924-3927 Email: consolidatedirrigation@comcast.net . Spokane Valley WA 99016 official website and that any information you provide is encrypted info@spokaneaquifer.org, Local Water Utilities United for Safe Drinking Water, 120 N. Greenacres RoadGreenacres, WA 99016, Backflow Protection & Cross Connection Control, eBook: Household Waste & Water Conservation, Middle School Water Conservation Trailhead, Click here for answers to frequently asked questions . <>
The novel gene candidates in the six genome-wide significant loci are highlighted in bold. Genetic variation in MYO10 has previously been linked to type 2 diabetes (Salonen et al., 2007) and traits of metabolic syndrome (Zhang et al., 2013). Karczewski KJ, Francioli LC, Tiao G, Cummings BB, Alfldi J, Wang Q, Collins RL, Laricchia KM, Ganna A, Birnbaum DP et al. We further assessed the robustness of our PCOS definition by comparing the effects sizes between the lead variants in the replicated loci presented in the non-NIH Rotterdam criteria (Day et al., 2018) to our association results. Harquahala Valley Irrigation District 25. The analysis conditioned on I157T resulted in no genome-wide significant associations in this locus, with a P-value of 0.04 for the lead variant rs182075939 (Fig. Finnish Institute for Health and Welfare, Helsinki, Finland. We were also able to replicate signals commonly reported in PCOS GWASDENND1A, ERBB4 (HER4), ZBTB16 and FSHBin our North-European populations. If a local agency is not managing its groundwater sustainably, SGMA directs the State Water Resources Control Board (State Water Board) to protect the groundwater resource until that local agency can sustainably manage the groundwater in its basin. A full list of FinnGen contributors can be found in Supplementary Data. An elected, threemember Board of Directors governs the District, which has . Also, BMI data were not available for all (63% for FinnGen, 76% for EstBB), and the biobank setting limited the accessibility of PCOS phenotypes and laboratory values. Serum anti-Mullerian hormone levels remain high until late reproductive age and decrease during metformin therapy in women with polycystic ovary syndrome. This results in follicle arrest and an increase in the number of antral follicles in the ovaries, as well as a 2- to 3-fold increase in levels of anti-Mllerian hormone (AMH) (Silva and Giacobini, 2021). Piltonen T, Morin-Papunen L, Koivunen R, Perheentupa A, Ruokonen A, Tapanainen JS. 2069, Consolidated Irrigation District, Corcoran Irrigation District, Empire West Side Irrigation District, Fresno Irrigation District, James Irrigation District, Kings County Water District, Kings River Water District, Laguna Irrigation District, Lakeside . The horizontal dashed line represents the threshold for genome-wide significance. Nelis M, Esko T, Mgi R, Zimprich F, Zimprich A, Toncheva D, Karachanak S, Piskkov T, Balak I, Peltonen L et al. Li J, Eriksson M, Czene K, Hall P, Rodriguez-Wallberg KA. Thus, we mainly focused on age-adjusted associations and acknowledge that larger sample sizes are needed to further explore the interplay between BMI and PCOS-related genetic factors. Prohaska A, Racimo F, Schork AJ, Sikora M, Stern AJ, Ilardo M, Allentoft ME, Folkersen L, Buil A, Moreno-Mayar JV et al. 2014 CCR Water QualityReport The lead variant rs182075939 was an intron variant located 22 kb from the TSS of TTC28 (Figs 1B and and2C).2C). Included adjustments were age, genotyping batches and the first 10 PCs. ), the Academy of Finland grants 315921 (T.P. stream
Body mass index and polycystic ovary syndrome: a 2-sample bidirectional Mendelian randomization study. Department of Clinical Genetics, Faculty of Medicine and Health Technology, Tampere University Hospital and Tampere University, Tampere, Finland. Adam Claes . the contents by NLM or the National Institutes of Health. MAIN RESULTS AND THE ROLE OF CHANCE. Estimated Deposits can be found here. Mustofa MK, Tanoue Y, Tateishi C, Vaziri C, Tateishi S. Roles of Chk2/CHEK2 in guarding against environmentally induced DNA damage and replication-stress. Overall, it is important to note that complex LD patterns between association signals might eclipse more distant causal genes. We then conducted a three-stage casecontrol GWAS: in the discovery phase, we had a total of 797 cases and 140558 controls from the FinnGen study. Learn more Regulatory Compliance CID is responsible for local, state and federal regulatory compliance and reporting. Mitt M, Kals M, Prn K, Gabriel SB, Lander ES, Palotie A, Ripatti S, Morris AP, Metspalu A, Esko T et al. 1000 Genomes Project Consortium Careers, Unable to load your collection due to an error. The value of studying genetic isolates, such as the Finnish population, has been accepted for decades (Martin et al., 2018). 2015 CCR Water Quality Report ), Finska Lkaresllskapet (H.L.) Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. Consolidated Irrigation District No. Christmas Eve Christmas Day. Vink JM, Sadrzadeh S, Lambalk CB, Boomsma DI. Greville-Heygate SL, Maishman T, Tapper WJ, Cutress RI, Copson E, Dunning AM, Haywood L, Jones LJ, Eccles DM. We identified three novel genome-wide significant associations with PCOS, with two putative independent causal variants in the checkpoint kinase 2 (CHEK2) gene and a third in myosin X (MYO10). Haplotype sharing provides insights into fine-scale population history and disease in Finland. Biocenter Oulu, University of Oulu, Oulu, Finland. Pasadena Park Irrigation District #17. Distinct subtypes of polycystic ovary syndrome with novel genetic associations: an unsupervised, phenotypic clustering analysis. Pay Online Now; Account & Payment History; Billing & Allowances; Rates; Start New Service; New Construction. x[oF?F]@Q`ri1E(3pigKpZt8k-"5=N}[o[s=tK{i}]w~Pglu|tQnJ;>2*%N Kuusisto KM, Bebel A, Vihinen M, Schleutker J, Sallinen SL. _Z}>>J?jZ||ti]ReSr\On|W/T2CL|04KtQ*o||qZfcu,G_bu#
6(D^aYy>T']@PBFE4 The lead variant of FinnGen data had a P-value of 0.031 in the EstBB. zCall: a rare variant caller for array-based genotyping: genetics and population analysis. Interestingly, even though the association signals found in the EstBB and FinnGen data sets overlap with each other (Fig. A total of 2812 cases and 89230 controls were included in the analyses. Click below for rates and allowances. Metabolic syndrome in polycystic ovary syndrome: a systematic review, meta-analysis and meta-regression. Sprinkler systems are required to have a backflow prevention device. In both cases, the lead single nucleotide polymorphisms had tightly linked variants, a frameshift (c.1100delC) and a missense (I157T), in the CHEK2 gene. endobj
Department of Obstetrics and Gynecology, PEDEGO Research Unit, Medical Research Centre, Oulu University Hospital, University of Oulu, Oulu, Finland. Public hearings were advertised through email updates, notices posted in the Selma Enterprise, and this website. Pay Your Bill Online * New Customers Backflow Testing Water Saving Tips * When paying your bill online please enter your account number only - if you enter your address it confuses the Invoice Cloud system. Irrigation Districts Cities Friant-Kern Canal 99 | State Highways 0 See individual district mapsfor Spheres of Influence 5 1015Miles Alpaugh Irrigation District Thus, it has been suggested that rare variants with larger effect sizes may contribute to the heritability of PCOS (Dapas and Dunaif, 2020). Testing is due annually by July 30th, and failure to provide acceptable test results by the due date may result in fines. Genetic structure of Europeans: a view from the NorthEast. Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland. Blank form to provide to your certified tester - Backflow Prevention Assembly Test Report Email a photo of the completed Backflow Report to cidoffice@comcast.net We fitted a logistic model where PCOS was the outcome, the lead variant genotype and BMI formed the interaction term, and the 10 first genetic PCs along with age were added as covariates. Consolidation Irrigation District Copyright 2023 - All Rights Reserved. Up to 12,000 cubic feet at $3.50/1,000 cubic feet. S1). Furthermore, as several studies suggest a causal role for obesity in PCOS (Legro, 2012; Brower et al., 2019; Zhao et al., 2020), we examined the influence of BMI on the detected associations with PCOS. In this analysis, the FinnGen lead variant rs145598156 remained genome-wide significant (P = 4.5108, OR = 13.5 [5.3534.38]) (Table I and Supplementary Fig. The main strength of this study was the use of the two large, comprehensive genetic data sets, FinnGen and the EstBB, which have been extensively linked to national registers, such as the CRCH in Finland and the Estonian Health Insurance Fund registries in Estonia, as well as with other relevant databases (Leitsalu et al., 2015). (509) 924-3656 High imputation quality markers (INFO score > 0.7) were kept from each study prior to the meta-analysis. When the FinnGen and EstBB results were conditioned for the c.1100delC and I157T variants and the results were meta-analyzed, there were no additional genome-wide significant signals in the CHEK2 locus. CID provides irrigation water deliveries, water right protection, groundwater management and rechar Consolidated Irrigation District | Selma CA However, this does not apply to other gynaecological cancers like ovarian, cervical or breast cancer (Barry et al., 2014; Gottschau et al., 2015; Hart and Doherty, 2015; Harris and Terry, 2016; Ding et al., 2018). Finally, we performed a joint meta-analysis of 3609 cases and 229788 controls from both cohorts. The Biobank access decisions for FinnGen samples and data utilized in the FinnGen data freeze R6 include: THL Biobank BB2017_55, BB2017_111, BB2018_19, BB_2018_34, BB_2018_67, BB2018_71, BB2019_7, BB2019_8, BB2019_26, BB2020_1, Finnish Red Cross Blood Service Biobank 7.12.2017, Helsinki Biobank HUS/359/2017, Auria Biobank AB17-5154, Biobank Borealis of Northern Finland_2017_1013, Biobank of Eastern Finland 1186/2018, Finnish Clinical Biobank Tampere MH0004, Central Finland Biobank 1-2017 and Terveystalo Biobank STB 2018001. A validation GWAS was performed in the EstBB, including 2812 cases and 89230 controls. The District currently serves more than 600 customers. government site. This study encourages the use of isolated populations to perform genetic association studies for the identification of rare variants contributing to the genetic landscape of complex diseases such as PCOS. The Finnish population originates from a small founder population with several bottleneck events over centuries, followed by genetic drift. In order to synchronize the build of the datasets, we lifted the FinnGen GWAS summary statistics over to hg37 build using UCSC liftOver (Kent et al., 2002) before running the meta-analyses. The FinnGen study was approved by Finnish Institute for Health and Welfare (permit numbers: THL/2031/6.02.00/2017, THL/1101/5.05.00/2017, THL/341/6.02.00/2018, THL/2222/6.02.00/2018, THL/283/6.02.00/2019, THL/1721/5.05.00/2019, THL/1524/5.05.00/2020 and THL/2364/14.02/2020); Digital and population data service agency (permit numbers: {"type":"entrez-protein","attrs":{"text":"VRK43431","term_id":"1645284850","term_text":"VRK43431"}}VRK43431/2017-3, VRK/6909/2018-3, VRK/4415/2019-3); the Social Insurance Institution (permit numbers: KELA 58/522/2017, KELA 131/522/2018, KELA 70/522/2019, KELA 98/522/2019, KELA 138/522/2019, KELA 2/522/2020, KELA 16/522/2020); and Statistics Finland (permit numbers: TK-53-1041-17 and TK-53-90-20). Hannele Laivuori, To Resolution 2020-3 %PDF-1.5
Conditioning the discovery analysis on I157T had a minimal effect on the genome-wide significant associations in this locus, with a P-value of 9.091012 for the lead variant rs145598156. The Coordinating Ethics Committee of the Hospital District of Helsinki and Uusimaa (HUS) approved the FinnGen study protocol (Nr HUS/990/2017). The odds ratios (dots) and 95% CI (whiskers) are shown for the two included cohorts and the meta-analysis. As the effect sizes remain largely unchanged when adjusted for BMI, the statistical significance of the associations was diluted by the reduction in sample size. Commercial Rates Apartment Rates Apartment Notes: Excess usage - $3.50/1,000 cu. endobj
Genes showing relevant functions in relevant tissues or traits with similar PCOS pathophysiology were ultimately considered for gene candidate prioritization. Wu P, Li R, Zhang W, Hu H, Wang W, Lin Y. Polycystic ovary syndrome is causally associated with estrogen receptorpositive instead of estrogen receptornegative breast cancer: a Mendelian randomization study. Natlia Pujol-Gualdo, Lim SS, Kakoly NS, Tan JWJ, Fitzgerald G, Bahri Khomami M, Joham AE, Cooray SD, Misso ML, Norman RJ, Harrison CL et al. For validation, we used an independent dataset from the Estonian Biobank, including 2812 cases and 89230 controls. Genome-wide analysis of single nucleotide polymorphisms uncovers population structure in northern Europe. Aguila Irrigation District 5. Sample genotyping in FinnGen was performed using Illumina and Affymetrix arrays (Illumina Inc., San Diego, and Thermo Fisher Scientific, Santa Clara, CA, USA). ), Novo Nordisk Foundation grant NNF17OC0026062 (J.K.), the Sigrid Juselius Foundation project grants (T.L., J.K., T.P. The mutational constraint spectrum quantified from variation in 141,456 humans. Bethesda, MD 20894, Web Policies Federal government websites often end in .gov or .mil. A discovery GWAS with 797 PCOS cases and 140558 controls in the FinnGen study uncovered two loci close to ERBB4 and DENND1A that have previously been shown to be associated with PCOS. Zhang Y, Kent JW Jr, Olivier M, Ali O, Cerjak D, Broeckel U, Abdou RM, Dyer TD, Comuzzie A, Curran JE et al. Whereas the association of CHEK2 c.1100delC with a moderate-risk breast cancer predisposition is well recognized (Meijers-Heijboer et al., 2002), the pathogenic role of I157T remains controversial (Schutte et al., 2003; Kilpivaara et al., 2004; Muranen et al., 2016). Brower MA, Hai Y, Jones MR, Guo X, Chen YI, Rotter JI, Krauss RM, Legro RS, Azziz R, Goodarzi MO. East Spokane Water District No. The Central Kings GSAs jurisdiction includes portions of the Kings Subbasin excluding the service areas of South Kings GSA. Loh PR, Danecek P, Palamara PF, Fuchsberger C, A Reshef Y, K Finucane H, Schoenherr S, Forer L, McCarthy S, Abecasis GR et al. Since considering most significant variants as the causal ones would lead to an underestimation of the total variance explained at each locus, we next performed conditional analyses, which were carried out similarly to the main association testing using SAIGE (Zhou et al., 2018). 2022 Consolidated Irrigation District No. This work has received funding from the European Unions Horizon 2020 research and innovation programme under the MATER Marie Skodowska-Curie grant agreement No. It was also reported that a CHEK2 loss-of-function allele is associated with later menopausal age in humans (Ruth et al., 2021). Information on the ICD codes was obtained via regular linking with the National Health Insurance Fund and other relevant databases (Leitsalu et al., 2015). matters concerning the Hospital District of Helsinki and Uusimaa (HUS) to the Market Court. The findings emphasize the benefits of utilizing isolated populations in genetic studies of complex diseases and advance the understanding of genetic factors underlying PCOS. Exhibit A Thus, when we tested for such an interaction between PCOS, c.1100delC, and obesity using a logit regression model, a P-value of 0.066 for c.1100delC-BMI interaction was obtained (OR 1.04, 95% CI 0.991.09). HHS Vulnerability Disclosure, Help J.S.T., R.K.A., N.P.-G., L.M.-P., T.T.P., T.L., J.K. and H.L. Genome-wide significant variants in FinnGen data are denoted with purple circles; Estonian Biobank-specific variants are not circled. Tambets K, Yunusbayev B, Hudjashov G, Ilume A, Rootsi S, Honkola T, Vesakoski O, Atkinson Q, Skoglund P, Kushniarevich A et al. A compendium of uniformly processed human gene expression and splicing quantitative trait loci. Although our results did not support such an association between c.1100delC-related PCOS risk and obesity, a replication of this analysis with larger sample size is needed. The Central Kings GSA was formed on November 8, 2017. Spokane Business & Industrial Park. The backflow testing process checks your plumbing to ensure dirty water does not infiltrate the drinking water supply. Erbb4 regulates the oocyte microenvironment during folliculogenesis. The Consolidated Irrigation District (CID or District) is seeking approval from landowners to increase its assessments on land in the District. This analysis included 2619 cases and 160321 controls, and a total of 24461102 genetic markers were analyzed. Interestingly, the identified variant seems to be associated with the age at menarche (Kichaev et al., 2019), indicating a reproductive function for MYO10. Summer Commercial Excess Rates We proceeded to test associations using a stepwise analysis, where markers were added to the model until no independent signals were identified. CE,"$G. and Jane and Aatos Erkko Foundation (H.L.). Martin AR, Karczewski KJ, Kerminen S, Kurki MI, Sarin A, Artomov M, Eriksson JG, Esko T, Genovese G, Havulinna AS et al. In conclusion, we identified two rare population-enriched variants located in CHEK2 that are significantly associated with PCOS. A final plan was submitted to the Board of Directors for a vote of approval at their meeting on March 9, 2022. National Library of Medicine Forest plot of effect estimates for the seven lead variants associated with PCOS. de Ziegler D, Pirtea P, Fanchin R, Ayoubi JM. Similarly, I157T, the likely association-driving variant in the EstBB, has a substantially higher allele frequency in the Estonian (0.048) and Finnish (0.029) populations, compared to the non-Finnish, Northwestern European population (0.0025), according to the gnomAD database (Karczewski et al., 2020). We considered two signals to colocalize if the posterior probability for a shared causal variant was 0.8 or higher. In a recent preprint work, Ward et al. When conducting a phenome-wide association study (PheWAS) on their associations, an aggregate of CHEK2-damaging variants also associated with PCOS, which is in line with our findings (Ward et al., 2021). ), 297338 (J.K.), 307247 (J.K.), 344695 (H.L. The .gov means its official. Although a metabolic link between MYO10 and PCOS seems likely, further research is needed to characterize the role of MYO10 in PCOS. endobj
Deletion of Chk2 in mice leads to a maximized ovarian reserve at postnatal day 2 (Tharp et al., 2020) and reduced follicle atresia, a higher number of ovulated metaphase II oocytes, and higher AMH levels at 13.5 months (Ruth et al., 2021). 2255 Chandler Ave | PO Box 209 Selma | Phone: 559-896-1660 | Fax: 559-896-8488. In the meta-analysis, the FinnGen lead variant on chromosome 22 rs145598156 had a P-value of 3.6108 with significant heterogeneity between cohorts (phet=9.58106), while the EstBB lead variant rs182075939 showed a P-value of 1.91016 in the meta-analysis results without significant heterogeneity between cohorts (phet = 0.3). endobj
Functional characterization of this locus revealed a frameshift variant, c.1100delC (rs555607708, P = 1.68109, OR = 13.46 [5.6831.89]) in CHEK2, with a high LD (r2 = 0.95) with the lead variant. Triin Laisk, S2). Loci were defined by 1000 kb of the top single nucleotide variant in the region. The international evidence-based guideline recommends using the Rotterdam criteria for PCOS diagnosis, requiring the presence of at least two of the following symptoms: oligo- or anovulation, clinical or biochemical hyperandrogenism, or polycystic ovaries seen in ultrasound, after exclusion of related disorders (Teede et al., 2018). The Consolidated Irrigation District ("CID") made a Public Records Act request for certain public records in City's possession regarding the CEQA proceedings.
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