BMC Med 2009; 7:25. There is a possible interaction between selenium and cisplatin, a type of chemotherapy used to treat cancer. National Institutes of Health - Office of Dietary Supplements. People who are deficient in selenium may develop various diseases. However, for me the benefits of selenium appear after just 10 days, and I think that is too fast to be due to toxic metal detoxification, which takes many months. But there is also some evidence that selenium may decrease the toxic side effects of cisplatin. JAMA 2011; 306:1549-1556. This includes hepatitis viruses and influenza and viral encephalitis. 2020 Sep 4;:1-2]. Some evidence suggests that selenium may help prevent and treat type 2 diabetes. Subchronic oral toxicity studies of Se-methylselenocysteine, an organoselenium compound for breast cancer prevention. Lee JH, et al: A novel activation-induced suicidal degradation mechanism for Akt by selenium. A diet rich in selenium may help keep your heart healthy, as low selenium levels have been linked to an increased risk of heart disease. Treatment with sodium selenate was performed in Epm2b / mice at 9 months of age. Int J Endocrinol. Fairweather-Tait SJ, et al: Selenium in Human Health and Disease. Fang MZ, Zhang X, Zarbl H. Methylselenocysteine resets the rhythmic expression of circadian and growth-regulatory genes disrupted by nitrosomethylurea in vivo. A healthy thyroid gland is important, as it regulates your metabolism and controls growth and development (22). Bleys J, et al. The epidemiology of selenium & human cancer. Serum selenium and peripheral arterial disease: results from the national health and nutrition examination survey, 2003-2004. The addition of selenium yeast or sodium selenite in the cow feeds increases significantly selenium content , the percentage of the polyunsaturated fatty acids (PUFA) and linoleic acid content in milk compared to the control . Johnson WD. The major driving factor of the global sodium selenite market is increasing demand from feed additives, the food industry, the glass industry, other applications. An original discovery: selenium deficiency and Keshan disease (an endemic heart disease). Lippman SM, et al: Effect of Selenium & Vitamin E on Risk of Prostate Cancer and Other Cancers: The Selenium & Vitamin E Cancer Prevention Trial (SELECT). Suzuki M. Differential apoptotic response of human cancer cells to organoselenium compounds. Selenium is a trace mineral commonly found in the soil of most regions of the world. Introductory Limited Time Offer for New Customers! Thioredoxin Reductase-1 Negatively Regulates HIV-1 Transactivating Protein Tat-dependent Transcription in Human Macrophages. Sodium Selenite has immense health benefits. What are the benefits of sodium selenite? The following foods are great sources (33), (34): The amount of selenium in plant-based foods varies depending on the selenium content of the soil in which they were grown. Table 1: Tolerable Upper Intake Levels (ULs) for Selenium, Cardiovascular disease including atherosclerosis and strokes, Arthritis including osteoarthritis, rheumatoid arthritis and psoriatic arthritis, Neurological diseases including Alzheimer's disease, Pancreatitis (inflammation of the pancreas), Thyroid Problems both under and overactive thyroid states. One review concluded that taking selenium supplements daily for three months resulted in lower thyroid antibodies. Dennert G, et al. Selenite is a stone symbolizing purity and spirituality. The pentahydrate Na 2 SeO 3 (H 2 O) 5 is the most common water-soluble selenium compound. Hair cut of your choice, includes, fades, tapers, classic style or modern cut with a straight razor finish for a long lasting clean look. Trace elements in hemodialysis patients: a systematic review and meta-analysis. Research suggests that people who have asthma have lower blood levels of selenium. Selenium supplements may contain higher levels of the mineral than you need. Hand Crushed and Sized by Rise Perspective 1mm 1oz. HIV Clin Trials 2002; 3:483-91. Bjelakovic G, et al. December 9, 2008. Supplemental Se-met, compared with selenite or selenate, also has differential effects on lymphocyte proliferation and other immunological variables (31, ,32). Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Summary Selenium may help keep your heart healthy by keeping oxidative stress in check and reducing your risk of heart disease. Barger JL, et al. Published 2021 Nov 23. doi:10.3390/molecules26237084, Ventura M, Melo M, Carrilho F. Selenium and thyroid disease: from pathophysiology to treatment. Looking to add more selenium to your diet? Vinceti M, et al. There are guidelines called Dietary Reference Intakes (DRIs) for taking selenium daily. Iron is an essential mineral, but ingesting too much can cause severe harm. Asia Pac J Clin Nutr 2012; 21:320-6. Chen XJ, Duan FD. Dietary Reference Intakes: Vitamin C, Vitamin E, Selenium, and Carotenoids. Getting selenium through food rather than supplements is thought to be safer and more effective. USDA National Nutrient Database for Standard Reference, Release 25. Webperoxides.1,2 Sodium selenite is included in medium supplements for use in cell culture (Catalog Numbers I1884 and S5666). There is some belief that selenium levels may factor into COVID-19 infection and infection severity. If you're thinking of using selenium supplements, talk with a healthcare provider first to learn how to use them safely. This means that selenium levels may vary depending on your country or region. Is important for thyroid health. Willett WC, et al. Alzheimers disease is a devastating condition that causes memory loss and negatively affects thinking and behavior. Asthma has been associated with increased levels of oxidative stress and inflammation in the body (29). Best Low Sodium Dog Food: Quick Picks. Kupka R, et al. Superoxide flashes: early mitochondrial signals for oxidative stress-induced apoptosis. Rayman MP, et al. 1. This may explain why one study found that regions of China with higher levels of selenium in the soil had decreased rates of COVID-19 infections. Its name comes from the Greek word Selene which means moon due to its color and appearance. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. A randomized controlled trial. Researchers found that when selenium was part of an antioxidant supplement, the risk for heart disease and all-cause mortality (death fro all sources) was lower than when selenium or antioxidants were taken separately. Liver selenium concentration in Se-depleted rats was 6.3% of controls . The increase of these parameters is more pronounced in case of selenized yeast as compared to sodium Learn about 20 selenium-rich foods, from lean meats to fruits and vegetables. Our results demonstrated a significant inhibition of pancreatic cancer However, more research is needed. An essential antioxidant. Selenium may interact with various medications and may not be appropriate for all health conditions. However, the full benefits of adequate Se status during S. aureus infection may not be achieved except under conditions of high bacteremia, because only injection of high Burk RF. Reid SM, et al. Interventions for clinical and subclinical hypothyroidism in pregnancy. Dietary supplements: what you need to know. Selenium deficiency has been associated with thyroid conditions like Hashimotos thyroiditis, a type of hypothyroidism in which the immune system attacks the thyroid gland. Kieliszek M. Seleniumfascinating microelement, properties and sources in food. Another study in mice found that sodium selenite might stunt growth and harm cellular structures, but selenomethionine only provides beneficial effects. Office of Disease Prevention and Health Promotion. Arch Intern Med 2010; 170:256-61. Am J Clin Nutr 2006; 84:762-73. These include bacteria, viruses, and parasites. 2021;8:696024. 2022;11(2):251. doi:10.3390/antiox11020251, Hu W, Zhao C, Hu H, Yin S. Food sources of selenium and its relationship with chronic diseases. Lancet 2000; 356:233-41, Rayman MP, Dietary selenium; time to act, British Medical Journal, Vol. Redman C, et al. 2. Hu YJ, et al. Nutrients. Li Z, Shi K, et al: ROS leads to MnSOD upregulation through ERK2 translocation and p53 activation in selenite-induced apoptosis of NB4 cells. Estimation of antioxidant intakes from diet and supplements in U.S. adults. Selenium can be available both in organic compounds (selenomethionine and selenocysteine) and in inorganic compounds (selenite and selenate) [].Considering that the organic form has better absorption, it seems to be the preferable formulation for supplementation or treatment WebThe number of electrons in each of Sodium's shells is [2, 8, 1] and its electron configuration is [Ne] 3s 1. Curr HIV Res 2007; 5:129-37. Flores-Mateo G, et al. Shahar A, et al. However, things like smoking, alcohol use, and stress can cause an excess of free radicals. Inhibitory effect of selenomethionine on the growth of three selected human tumor cell lines. Please review supplement labels with a healthcare provider to discuss any potential interactions with foods, other supplements, and medications. More research is needed. Klein EA, et al. Am J Clin Nutr 2008; 87:1802-8. May reduce your risk of certain cancers, 10 Signs and Symptoms of Iodine Deficiency, 7 Nutrient Deficiencies That Are Incredibly Common, The Dark Side of Iron - Why Too Much is Harmful, 10 Magnesium-Rich Foods That Are Super Healthy, The 4 Best At-Home Vitamin D Tests of 2023, 11 Best Postnatal Vitamins of 2023, According to a Dietitian. Selenite is a protective stone that will help keep negative energies away. Labunskyy VM, Hatfield DL, Gladyshev VN. 2021;26(23):7084. The number of people with Alzheimers disease is growing. Many foods contain selenium. Allen NE, et al. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. For example, one study found that oral selenium supplements improved overall quality of life and reduced radiation-induced diarrhea in women with cervical and uterine cancer (10). Host nutritional selenium status as a driving force for influenza virus mutations. WebThe supplement gives 200 mcg of the mineral in the form of sodium selenate. Additionally, browse dog food with Sodium Selenite Benefits. Village Rock Shop. Nutr Cancer 2011; 63: 1185-1195. Handle with extreme caution. Additionally, some studies have shown that selenium supplements may benefit people with Hashimotos disease. Brazil nuts contain a very high amount of selenium. Sodium selenite, an antioxidant commonly used in serum-free media, demonstrates strong anti-angiogenic properties and has been proposed as an anticancer drug. Incorporating selenium-rich foods into your diet is a great way to keep levels of oxidative stress and inflammation to a minimum. For example, one study showed that the selenium concentration in Brazil nuts varied widely by region.